Royal Air Force Typhoon jets have operated alongside France's air force in a combined operation on an underground arms cache in Syrian territory employed by the IS group, per a report from the British defence ministry.
The facility, located using intelligence, was assessed as storing arms and explosives, the announcement noted, and was positioned in mountainous terrain just to the north of the ancient city of Palmyra in Syria's central region.
"Our fighter planes employed laser-guided Paveway IV weapons to target a series of approach shafts leading to the site... early reports suggest the target was engaged successfully," the ministry announced.
There was no indication of any civilian casualties in the attack on Saturday evening and all the aircraft made a safe return, the MoD added.
The Typhoon fighters were assisted by a Voyager refuelling tanker.
Daesh - referred to as Daesh - established jihadist rule over significant areas in both Syria and Iraq until 2019.
"This strike demonstrates our UK leadership, and determination to operate in unison with our allies, to stamp out any resurgence of Daesh and their dangerous and violent ideologies in the region," UK Defence Secretary John Healey stated.
British military aircraft have carried out overwatch operations over Syrian airspace to "prevent any attempted resurgence" of IS after its military defeat at the battle of Baghuz in the year 2019, the ministry said.
"I want to thank all the members of the UK armed forces who took part in this operation for their skill and their valour," the Defence Secretary commented. "They were among numerous UK service members on duty over the festive period. This action, to remove militants who pose a risk to our safety, demonstrates how UK forces are ready to step up, all year round, keeping Britain secure at home and powerful internationally."
During December, the US military carried out what it called a "large-scale strike" targeting Islamic State objectives in the country, after an ambush resulted in the deaths of two American soldiers and a civilian interpreter in Palmyra.
The United Nations reports IS still maintains an estimated 5,000 to 7,000 militants in Iraq and Syria.